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This not only interferes with vascular homeostatic signaling chemically (via production of free radicals), but also physically through separation of the endothelium from smooth muscle cells, and, at later stages, by disrupting the endothelial cell monolayer [25, 52]

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Virginia Governor Tim Kaine (D) has proposed a 100% increase (from 30 cents to 60 cents) and South Carolina Governor Mark Sanford (R) has proposed a 400% increase (from 7 cents to 37 cents) as part of a comprehensive tax reform package