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(2006) A fluoro analogue of the menadione derivative 6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase

This strategy promotes the synthesis of adenosine triphosphate and energy metabolism in the sickle cell, while depleting the reservoirs of allosteric modulators like 2,3-diphosphoglycerate that promote sickling by stabilizing the tense deoxygenated state of hemoglobin

At physiologically appropriate levels, they are involved in cell signaling processes

Researchers developed PT-141 from the tanning peptide, Melanotan 2

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