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Benoist 2014, PMID 25187433, retracted 2025 per notice PMID 40312093) is potentiation of hepatocyte growth factor (HGF) signaling at the c-Met (MET) receptor, driving dendritic spine formation and synaptogenesis via PI3K-AKT

Initial studies in animal models suggested that pineal peptide extracts containing the AEDG sequence might extend lifespan and improve various markers of aging

Research on rat models with induced arthritis documents reduced cartilage degradation and improved limb function scores in BPC-157-treated subjects

The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy