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501 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the dysfunction of upper and lower motor neurons

CSCs have been linked to chemoresistance in cancer patients, which accounts for 90% of treatment failures

Semax , an ACTH(410) analog developed in Russia, has been extensively studied in academic settings for its influence on BDNF, NGF (nerve growth factor), and serotonergic signaling

The choice of therapy for primary prophylaxis depends on patient preferences and includes pharmacologic therapy with nonselective -blockers (NSBBs) or variceal band ligation, especially if NSBB therapy fails or is not tolerated by the patient

A prodrug is a biologically inactive or less active compound that is metabolized in the body into a pharmacologically active form