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Stressors in this category may include: Chronic work pressure, high-responsibility roles, or job insecurity Relationship strain, divorce, or family conflict Grief, loss, or prolonged uncertainty Unresolved emotional patterns, including chronic anxiety, suppressed anger, guilt, or fear Caring for a chronically ill family member Physical Stressors Physical demands on the body activate the HPA axis just as reliably as emotional ones

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However, these effects are not consistently proven in humans, and this therapy is considered investigational

Dig Dis Sci 2000;45:717

Mark the 28-day discard date alongside the puncture date calculating it once at puncture is faster than recalculating at each use