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Arif, H., & Aggarwal, S

Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions

That is how many years separate the 2014 Nature paper that put NNMT inhibition on the map [3] from wherever you are reading this in 2026

This condition remains untreated, yet it significantly influences cognitive decline and stroke incidence among older individuals

NNMT (Nicotinamide N-Methyltransferase) Inhibition Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM 4