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doi: 10.3389/fncel.2020.581950 Received 14 July 2020 Accepted 21 December 2020 Published 18 February 2021 Volume 14 - 2020 Edited by Danilo Bilches Medinas, University of Chile, Chile Reviewed by Jorge Matias-Guiu, Complutense University of Madrid, Spain

Is it true that this pathway is only active when the cell is under oxidative stress conditions

The mechanism is plausible (direct delivery should theoretically accelerate results), but the evidence base is not comparable to what exists for topical application

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