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We also need continued study of dual users to determine whether they maintain harm reduction over time. Ahluwalia said that because many individuals who use both e-cigarettes and combustible cigarettes will switch back to exclusively combustible cigarettes over time, there is a critical need for interventions that support those who try to switch to e-cigarettes but fail

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This is thought to be related to estrogens effects on fibrinolysis, the bodys clot-breaking system