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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Kopan and Ilagan, 2009)

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Clinical trial data in the literature examining the biological effects of glutathione intake is fragmented with no clear guidelines for the clinician especially in the management of skin pigmentation issues

The first-line test is serum vitamin B12 measurement , with levels below 148 pmol/L generally considered deficient, though the exact threshold varies between laboratories

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