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10.1016/j.it.2019.02.001 80 NuhuF.GordonA.SturmeyR.SeymourA

Oxidative stress is the overproduction of highly active molecules, such as ROS, and when liver cells are exposed to certain noxious stimuli, leading to an imbalance between the oxidative and antioxidative systems, liver injury occurs (20)

Because of the diverse functions of the TrxR- and GR-dependent pathways, the two oxidoreductases have been identified as promising targets for drug development for many diseases, including malaria, trypanosomiasis, and cancer [9,10]