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Introduction Diabetic kidney disease (DKD) is a common diabetic complication, the incidence of which is about 30% in patients with type 1 diabetes mellitus (T1DM) and about 40% in patients with type 2 diabetes mellitus (T2DM) worldwide ( Previous studies have shown inflammation, fibrosis, and apoptosis leading to progressive loss of kidney function in the progression of DKD ( Hydroxyurea (HU) is a therapeutic agent approved by FDA to treat sickle cell disease (SCD) ( In this study, we postulated that HU could mitigate renal dysfunction in DKD mice by inhibiting inflammation and apoptosis