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Many arginase inhibitors with high affinity have been developed over the past several decades, such as N-hydroxy-L-arginine [NOHA, K i = 3.6 M for human ARG1 ( d = 0.47 M for human ARG1 ( 50 values of derivatives range 171,470 nM for human ARG1, 302,150 nM for human ARG2 (Ilies et al., 2011)] and S-(2-boronoethyl)-l-cysteine (BEC) [K i = 0.40.6 M (Pudlo et al

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F.ZhangS.ZhaoF.LiY.et al (2008b)