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doi: 10.1016/j.pharmthera.2018.11.010 52 Kabat-ZinnJ

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By 2023 this had dropped 52% to just 88.1 billion units, a fall of 94.2 billion units, while the sale of the tobacco sticks used in HTP that year had risen to 72 billion units in under 10 years

In the CNS large doses induce a generalised mental depression, tremors, nausea, and convulsions