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Histological Evaluation Liver tissue samples were fixed in 10% neutral-buffered formalin for histological evaluation

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Before initiating treatment with selective FGFR inhibitors, patients and their caregivers should be well informed about the AEs they may expect during treatment, and that these AEs are generally manageable with appropriate prophylaxis, proactive monitoring, and timely treatment

mTORC2 interacts with IGF-IR, and phosphorylates IGF-IR at Y1131/1136 thereby activating IGF-IR [32]