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3, Ti values were substantially lower at the + 5 and + 30 min time-points post-fentanyl in the GSHee-treated rats whereas Te values were equivalent to pre-values at both times, reinforcing the general observation that GSHee differentially effects the ventilatory effects of fentanyl

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including jun N-terminal protein kinases and p38 kinase by alkylating agents

M., Vargas-Torres, A., Zeugolis, D

Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice

Phase III trials and NAFLD studies confirmed these effects, which is what earned tesamorelin its FDA approval