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Acta 1860 , 836843 (2016)

The EMPA-REG and CANVAS trials showed that the SGLT-2i empagliflozin and SGLT-1/2i canagliflozin reduced the risk of MACE in T2D patients with or at high risk of CVD by 14%, while the SGLT-2i dapagliflozin did not significantly reduce the risk of MACE, possibly due to the difference in population (approximately 60% with no established ASCVD) between previous trials and strict exclusion criteria

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BPC-157 is a synthetic pentadecapeptide composed of 15 amino acids and derived from a naturally occurring sequence found within gastric proteins