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Sustained elevation of IL-10 serum concentrations achieved through pegylated IL-10 (pegilodecakin) also enhances cytotoxicity, expansion of tumor-specific CD8 + T cells, and their tumor-killing effects [117]

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Conjugation may decrease the solubility, plasma protein binding, and liver and reticuloendothelial uptake, thus altering the bioavailability of the drug