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A spokesperson for the Department of Health and Social Care said: We have introduced tough regulations to deter the appeal of vaping to children, including restrictions on product advertising, setting limits on nicotine strength, labelling and safety requirements, and making it illegal to sell nicotine vapes to those aged under 18 years old

It was first patented to treat malaria in 1999 by Glaxo Wellcome, which merged with another British pharmaceutical company called SmithKline Beecham in 2000 to form the pharmaceutical giant GlaxoSmithKline

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Tobacco Control 2003;12:391-395

The 2019 review notes that research indicates: People living with schizophrenia and severe nicotine dependence often report more severe positive and negative symptoms and require higher doses of antipsychotics