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A fast ADH or a slow ALDH are expected to elevate acetaldehyde levels and thus reduce alcohol drinking

Acknowledgments This work was supported by funding from the Idaho NASA EPSCoR Program, NIH/NIBIB (R03EB024134), INBRE program, P20 GM103408 (National Institutes of General Medical Sciences), and Beckman Scholars Award from the Arnold and Mabel Beckman Foundation (to NMP)

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I think it will be interesting once we start to see whether the combination of GLP-1s with other compounds that impact the glutamate pathway, particularly in the brain, will have meaningful impact on neurodegenerative diseases