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37,38 In some MDD patients, stress leads to long-term elevated glucocorticoids, resulting in synaptic structural changes and remodeling, and the stress-induced hyperactivity of the HPA axis leads to negative feedback imbalance of the HPA axis, which is also related to depression

1;149(1):42433 Poncin S, Colin IM, Grard AC (2009) Minimal oxidative load: a prerequisite for thyroid cell function

One molecule plays a central role in all of these processes: NAD+ (nicotinamide adenine dinucleotide)