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In oxidative stress models, cells treated with GHK-Cu show 65% reduction in malondialdehyde levels (a lipid peroxidation marker) and 80% increase in total antioxidant capacity compared to controls

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However, in comparison to the 2-MOE ASO, we found that the 2-F ASO bound the same protein interactors with higher enrichment factors at low ASO concentration, which is in accordance with the stronger affinity of the 2-F ASO for such binders and, thus, might reflect differences in binding constants

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