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It is important to note that off-label prescribing of combination weight loss medications may occur in some specialist settings, but this should only be undertaken by experienced clinicians who can provide close monitoring and have thoroughly assessed the individual patient's risk-benefit profile

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Tzang 2025 (18 RCTs): overweight/obesity regains +5.63 kg while type 2 diabetes regains +2.03 kg but rebounds harder on blood-sugar control (HbA1c +0.65 vs +0.25%)