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The choice of a stabilizing agent isn't arbitrary

For instance, the reader of m 6 A, insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), undergoes lactylation at K76, promoting the m 6 A modification of phosphoenolpyruvate carboxykinase 2 (PCK2) and nuclear factor erythroid 2-related factor 2 ( NRF2 ) mRNAs, which reprogram serine metabolism in HCC cells

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The excellent safety profile observed in obese participants suggests that AOD-9604 is well-tolerated even in individuals with obesity-related comorbidities