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One such enzyme, Cytochrome P-450 1A2 (CYP1A2), is responsible for activating polycyclic aromatic hydrocarbons (PAHs) found in substances like cigarette smoke, car exhaust, and charbroiled foods into carcinogenic intermediates

Claudin proteins are small (2027 kDa) transmembrane proteins expressed in tissue- and cell-specific manner, 12, 13 with a total of 27 claudin family members having been identified to date