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Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo

The study further elucidated the signaling pathway involved, showing that BPC 157 enhanced the phosphorylation of Src, Caveolin-1 (Cav-1), and endothelial nitric oxide synthase (eNOS)

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

Initial dosing starts at 200-300 mcg daily, administered subcutaneously, with gradual increases to therapeutic levels of 500-1000 mcg daily over 2-3 weeks

& Rivas, K