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doi: 10.1002/pros.22486 103 NemesureBWuS-YHennisALeskeMC

IEM are a class of inborn errors of metabolic pathways that are marked by accumulation (and usually toxic) organic acid metabolites in blood (i.e., organic acidemias) and increased excretion of organic acids in urine (i.e., organic acidurias)

The exact dose, amount, and concentration of DSIP vary depending on the delivery method, such as injection, nasal spray, or inhalation, and are crucial for effective and safe use

The UK's approach differs slightly from recommendations by the European Food Safety Authority (EFSA) , which sets an Adequate Intake of 4 mcg per day for adults, reflecting a more cautious margin of safety