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A coordinated interaction between immune cells, fibroblasts, keratinocytes, endothelial cells, and extracellular matrix components is needed in each of the phases

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Native IGF-1 added to cell culture media at the start of a 72-hour experiment will be substantially degraded and sequestered by the end of that window, even in serum-free conditions

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Torres TM, Almeida-Monteiro PSde, Nascimento RVdo, Cndido-Sobrinho SA, Sousa CTN, Ferreira YM, et al