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Disorders related to the cardiovascular system (exercise intolerance, chest pain, palpitations, thrombotic manifestations) are also frequent and potentially pathogenetically related to the dysfunction of the cardiovascular autonomic system

Mice with hepatocellular carcinoma and treated with XL413 (100 mg/kg) in combination with AZD8055 (20 mg/kg) exhibited significantly greater tumor mass reduction and increased lifespan compared to mice treated with monotherapy using either of these drugs [136]

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The fasting mimicking diet offers a promising adjunct to traditional treatments