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Low levels can impair energy production, leading individuals to feel constantly fatigued

For most of studies using MIA-induced model, the administration is performed in male mice aged 23 months, followed by analysis of the OA phenotype 12 months later

Studies investigating the regulation of ion channels relevant to mitochondrial iron transport and cardiac dysfunction due to iron overload have demonstrated that the MCU facilitates the transport of Fe2 + into the mitochondria, while Mfrn2 may serve a regulatory function in this process [11]