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GHK-Cu does not directly interact with cytoskeletal proteins but instead operates through copper-dependent enzymatic activation and transcriptomic reprogramming

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Depressive symptoms and immune transcriptional profiles in late adolescents

HCAR1 (GPR81) is a Gi-coupled receptor for lactate that is upregulated across multiple solid tumors (e.g., breast, cervical, pancreatic), where it promotes malignant phenotypes, including PI3K/AKT-dependent growth and angiogenesis [372]