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The key feature of this short peptide is its high concentration of one specific amino acid, proline, that provides an unusual kink in peptides and proteins and may delay or even prevent its degradation

Intrapancreatic fat deposition has been proposed to represent a key mediator of diseases of both the endocrine (i.e., type 2 diabetes) and exocrine pancreas (including PDAC and acute pancreatitis) 50

In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose

When smo was suppressed in the wing pouch, the transcription of hid-lacZ was markedly increased (Fig