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It is likely that somatostatin may have an additional sst 2 -mediated inhibitory action at the pituitary level where ACTH-secreting cells express the sst 2 (Day et al., In vitro studies showed that somatostatin-14 (Heisler et al., 1983) and somatostatin-28 (Strowski et al., 2002) as well as selective sst 2 and sst 5 agonists, unlike sst 1 , sst 3 , or sst 4 (Strowski et al., 2002) block the CRF-stimulated ACTH release from pituitary AtT-20 cells

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An extended beneficial effect was also apparent one week later, indicating rescue from ischemic colitis

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