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The GSSG/GSH redox couple plays a vital role in several enzymatic reactions, including the elimination of peroxides by GSH peroxidases (GPx), in covalent addition of cysteines to proteins by glutaredoxin , and in detoxification of electrophiles by GSH-S-transferase (GST) 585,586,587

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Higher NAD enhances SIRT1 activity, promoting fat oxidation and mitochondrial remodeling via PGC-1 pathwaysmechanisms consistent with improved endurance and recovery potential (Cant et al., Cell Metabolism

Magnesium glycinate doesnt draw water into the large intestine like magnesium oxide, as its bound with two glycine molecules, leaving no room for water to attach, as it would if you took magnesium oxide

This multi-level regulation keeps glutamate within its tight physiologic range. Excess causes excitotoxic neuronal death (as in stroke), while deficiency impairs learning and memory