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In the bile duct-ligated rats as well as in the occlusion-like syndrome and Budd-Chiarisyndrome rats [13,22,23,24,25], there was a consistent counteraction of the intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, aortal hypotension, and congested veins (i.e., reflecting trapped volumecongested inferior caval vein and superior mesenteric vein)

Mild changes in electrolytes are possible, particularly if GI side effects cause fluid loss

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But the response has not been better skepticism

Dose Range: From 0.25 mg up to about 4.5 mg weekly in advanced protocols, increased gradually [1]