gCSCs can develop drug resistance by affecting drug efflux, apoptosis, DNA damage repair, TME and EMT, as well as proliferate after escaping chemotherapy, eventually resulting in tumor recurrence and metastasis (62) ( Figure 5 )
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Sae-Lee C, Corsi S, Barrow TM, Kuhnle GGC, Bollati V, Mathers JC, et al
Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases
Synergistic Antioxidant Recycling: It has the rare ability to regenerate oxidized Vitamin C and Vitamin E, extending the lifespan of these antioxidants within a formulation and amplifying their effects