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doi: 10.1038/ncomms7129 466 YangL

According to the available scientific data, research experiments in rodents have lasted up to 45 days, with most studies ranging between 11-45 days or four weeks on average [3, 4, 7]

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Kuai Y, Liu H, Liu D, Liu Y, Sun Y, Xie J, Sun J, Fang Y, Pan H, Han W (2020) An ultralow dose of the NADPH oxidase inhibitor diphenyleneiodonium (DPI) is an economical and effective therapeutic agent for the treatment of colitis-associated colorectal cancer

Excessive NO contributes to lower esophageal sphincter (LES) relaxation, a primary driver of reflux events