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More specifically, the British National Formulary marks with bullet points potentially harmful drug pairs which should be prescribed cautiously, under appropriate monitoring, or avoided altogether (Drugs.com Drug Interaction Checker (DDIC) and DrugBank.com classify interactions into four severity levels: major, moderate, minor, and unknown (Tatro, 2014)

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[DOI] [PubMed] [Google Scholar] Hurt RD, Sachs DP, Glover ED, Offord KP, Johnston JA, Dale LC, Khayrallah MA, Schroeder DR, Glover PN, Sullivan CR, Croghan IT, Sullivan PM