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Thus, intrinsic TME conditions sensitized wild-type IDH1 to FDA-approved AG-120 (ivosidenib), and revealed the drug to be a potent single-agent therapeutic in cell culture and diverse in vivo cancer models

Treated with GSK3 inhibitor LiCl, the expression levels of the phosphorylated GSK3 (Ser9) was significantly upregulated, Bax and cle-Caspase3 protein were found to be significantly downregulated, and that of Bcl-2 was significantly upregulated in Prx II-knockout HaCaT cells after H 2 O 2 treatment(Fig

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As a result, aged animals produced oocytes with spindle defects leading to misaligned chromosomes (that will induce impaired cell division)