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Upon activation, the FXR binds to an FXR-responsive element in the 5 flanking region of the CSE promoter, while GPBAR-1 recruits CREB, a cyclic AMP responsive element (CRE) binding protein that binds to sites on the CSE promoter

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Immunological Risks: Peptide Hypersensitivity and Autoimmunity Exogenous peptides can act as haptens or immunogens, particularly if they are impure or conjugated to carrier proteins from the manufacturing process