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Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

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This is called adaptive thermogenesis. Resting metabolic rate (RMR) declines, thyroid hormone production decreases, and physical activity naturally drops

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