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Delphinidin has been demonstrated to inhibit the PI3K/Akt/mTOR signaling pathway in imiquimod-induced psoriasis, which is frequently upregulated in psoriatic lesions and contributes to the excessive proliferation of keratinocytes (Chamcheu et al

Sleep Med Rev 11(1):719 Irwin MR, Piber D (2018) Insomnia and inflammation: a two hit model of depression risk and prevention

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(All of this tracks with clinical and reviewlevel evidence that GHKCu can improve the appearance of firmness, elasticity, texture, and fine lines over time when used in creams.)