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DNA damage promotes mutations of suppressor in tumor such as calcium/calmodulin dependent serine protein kinase (CASK), p53, as well as stimulation of the epidermal growth factor receptor (EFGR) signaling pathway, which are important early events in gastric carcinogenesis (86, 87)

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Directs calcium into bones rather than soft tissues

Distinguished as a potent non-enzymatic antioxidant and free radical scavenger, melatonin possesses the unique ability to neutralize free radicals independently of receptors, owing to its distinctive chemical structure [93]

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