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Results HFD feeding induces overt hyperglycemia and prevents body weight gain in Insr P1195L/ + mice P1195L/ + The blood glucose levels of Insr P1195L/ + mice under normal diet (ND) ( Insr P1195L/ +/ND mice) were not different from those of wild-type (WT) mice

Headaches, nausea, diarrhea, fatigue, and tingling in extremities are very rare

Bioavailability: nearly 100%, bypasses GI absorption entirely Deficiency: first-line for pernicious anemia and malabsorption Dosing: weekly to monthly maintenance Prescription: yes, through Heally At home: yes, after provider guidance Daily tablets or lozenges

No weight loss as of yet

For individuals seeking support with obesity or weight management, NICE-approved pathways exist and should be the starting point