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In the search for UPS regulators to modulate PKA-pCREB levels in the brain, it was found that in the snail Aplysia , the ubiquitin C-terminal hydrolase (Ap-Uch, a homolog of vertebrate Uch-L1) enhances the degradation of the polyubiquitinated R subunit of PKA (Hegde et al., 1989

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Ebokaiwe AP, Okori S, Nwankwo JO et al (2021) Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats