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(2017) revealed that innate DNA sensing through cGAS governs the senescence program and the senescence-associated secretory phenotypes by detecting cytosolic chromatin fragments in senescent cells

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NNMT (nicotinamide N-methyltransferase) is an enzyme in adipose tissue that depletes NAD+ and promotes fat storage

Mechanisms implicated in hyperglycemia-driven tissue damage in diabetes include abnormal signaling through protein kinase C, elevated advanced glycation end products, and the aldose reductase pathway (1)

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