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The stress-activated protein kinase MAPK13 is responsive to various stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and is involved in cell differentiation, apoptosis, and autophagy [67]

ARC Is Regulated by MAPK and PI3K and Confers Drug Resistance and Survival Advantage to AML in vitro and in vivo

Kim DH et al (2011) Foxo6 integrates insulin signaling with gluconeogenesis in the liver

Hemodialysis is the first-choice treatment because it is available everywhere and must be started before being transferred to a center specialized in metabolic pathologies where other medical treatments are available [37]

And finally, potential synergy: therapies targeting hypoxia and HIF-1 may have the potential to create synergies with existing drugs compared to existing treatments, thereby enhancing the therapeutic effect (233)