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High IGF-1 levels, often caused by exogenous HGH use, can increase cancer risk, water retention, and insulin resistance

In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)

10.1523/JNEUROSCI.07-02-00604.1987 14

In more extreme cases, a deficiency could contribute to neurological issues, particularly in children

I get a rash and it burns for several hours