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However, in humans, proline has been known to be catalyzed by proline oxidase (POX), being regulated by age or by the peroxisome proliferator-activated receptor gamma (PPAR) regulator [132,133,134,135]

Given that Glu is primarily neuroactive while Gln is storable and neuroinactive, the Gln/Glu ratio can reflect the efficiency of Glu uptake by astrocytes and its conversion to Gln, which is crucial for regulating excitatory neurotransmission [20]

This therapy is used to treat primarily musculoskeletal injuries such as cruciate ligament injuries, prolapsed intervertebral discs, back pain and osteoarthritis

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