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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

Moreover, increased DNA oxidation is observed before obvious astrocyte death, while augmented free radical generation is concurrent with increased astrocyte damage

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High-fat diet induces disruption of the tight junction-mediated paracellular barrier in the proximal small intestine before the onset of type 2 diabetes and endotoxemia

This story was produced by Kaiser Health News, an editorially independent program of the Kaiser Family Foundation.