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140-142 It has been suggested that it acts as a satiety signal via CCK1 receptor activation on vagal afferents

A C-terminally substituted analogue of PTHrP 134, the RS-66271, was found to increase trabecular and cortical bone in ovarectomized osteopenic rats [54]

The aberrant methylation has been implicated as a pathogenic mechanism in psychiatric disorders, such as MDD, as outlined in the section of the review (below), and also in neurological diseases, such as AD, as outlined in later sections

Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice

Development of petrelintide: a potent, stable, long-acting human amylin analogue